Using psilocybin to quit smoking 

A study conducted in 2014 by researchers at Johns Hopkins University found that psilocybin, when combined with cognitive behavioral therapy, led to a significant reduction in smoking rates among participants.

The study involved 15 smokers who participated in two to three psilocybin-assisted therapy sessions, each two weeks apart. After the sessions, participants reported a decreased desire to smoke, decreased smoking behavior, and a reduction in cravings. Follow-up assessments conducted six months later found that 12 of the participants (80%) had quit smoking completely, while two others had reduced their smoking by more than 80%.

These results are all the more stunning when one considers that the most successful current treatment—the drug varenicline, which reduces nicotine cravings—only has a 35% success rate

However, it is important to note that this study had a small sample size and more research is needed to fully understand the potential benefits and risks of psilocybin therapy for smoking cessation.